Some Facts About Mupirocin Cream

Mupirocin is a natural antibiotic, which is a derivative of carbon monoxide acid for local application. The development of the drug involves the use of Pseudomonas fluorescens excreta.

Pharmacological properties

Mupirocin is a natural antibiotic, which is a derivative of carbon monoxide acid with a limited range of action. The drug has both antibacterial and bacteriostatic effect, depending on the concentration of antibiotic. The mechanism of action of Mupirocin is to suppress the enzyme isoleucine-transfer-RNA- synthetase, with the result that the synthesis of RNA and proteins in the bacterial cells is violated. To a lesser extent, it breaches the synthesis of RNA and suppress the synthesis of bacterial cell wall. The staphylococci, streptococci Haemophilus influenzae, Escherichia coli are sensitive to the drug. The most of gram-negative, anaerobic microorganisms and also representatives of normal skin microflora are insensitive to the drugs. The drug is used only locally, by means of applying on the damaged skin areas, or intra-nasally. Mupirocin is barely absorbed from the intact skin; the systemic absorption reaches 0.24% for the intact skin, and 1.2-5.1% in case of intranasal use. The drug forms high concentrations in the superficial skin layers. Mupirocin is metabolized in the skin with the formation of inactive metabolite — uric acid. This drug is excreted in urine (in the form of metabolites). Liver and kidney failure don’t prevent the elimination of Mupirocin.


Mupirocin is used for the local treatment of bacterial complications caused by the traumatic skin lesions (furunculosis, folliculitis, impetigo, erysipelas and trophic ulcers), external otitis and nasal carriage of staphylococcus.

Side effects

If you buy mupirocin without prescription, he can cause the following side effects: frequent (1-10% in case of external use) – urticaria, itching, flushing, skin rash, burning, dryness and eczema; very rare (in case of intranasal use and systemic absorption of the drug) – headache, vertigo, sickness, stomachache, stomatitis, cough, shortness of breath, ear pain, rhinitis and pharyngitis.


Mupirocin is contraindicated for the patients with an increased sensitivity to the drug. The drug must be used with caution during pregnancy and breastfeeding.

Pharmaceutical form

Mupirocin is available in 2% cream for external use (15 g) and 2% ointment for intranasal use (3 g).

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